Asthma is associated with acute chest syndrome, but not with an increased rate of hospitalization for pain among children in France with sickle cell anemia: a retrospective cohort study.

Asthma and sickle cell disease are two common chronic diseases that may exist as co-morbid conditions. Our group has recently demonstrated that asthma, the most common chronic disease among children, is a distinct co-morbid condition among children with sickle cell anemia (SCA) and has a similar prevalence among children with and without sickle cell disease. Furthermore, we have demonstrated that asthma is associated with an increased rate of both acute chest syndrome (ACS) and pain, the most common complication associated with SCA. The majority of the supporting data demonstrating the association between asthma and acute chest syndrome episodes has been documented in the United States. Given that asthma is related to genes and environment, we tested the hypothesis that the strength of the association between asthma and SCA morbidity would be confirmed in another country with a different genetic population and perhaps different environmental factors. Approval to conduct this retrospective study was obtained from the Institutional Review Board of the Washington University School of Medicine and the Ethics Committee for the Centre Hospitalier Intercommunal Créteil (CHIC). Approval was given to analyze the de-identified data of children with SCA who were followed at the CHIC from 1980 through 2007. Patients were followed at CHIC and were seen at least annually for interval history which consisted of a physical examination and evaluation of SCA-related morbidity, co-morbid conditions, medication histories, and laboratory testing that included complete blood count. Table 1 describes baseline features of children with and without a doctor-diagnosis of asthma. All children regularly receiving medical care in France carry un carnet de santé, i.e. a health notebook, which is used to document all information regarding their health and hospitalizations. From this health notebook, the lifetime hospitalization history was recorded in a database for all children followed at CHIC. The start of patient-year accumulation began on the date of birth for those born in France and on the date of the first clinical visit or hospital admission for those not born in France. The end of patient-year accumulation occurred when the earliest date of one of the following was documented: (i) the start of chronic blood transfusion therapy; (ii) the start of hydroxyurea therapy; (iii) the start of hematopoetic stem cell transplant; (iv) death, or (v) 18 birthday. The length of follow-up was at least six months, but not more than 18 years for any subject. ACS was defined as a new radiographical finding of the lungs associated with fever, respiratory signs or thoracic pain. A pain episode was defined as pain in the extremities, back, abdomen, chest or head that resulted in hospitalization. The diagnosis of asthma was made when a child with sickle cell anemia had 3 or more episodes of bronchiolitis under the age of two years or when wheezing was heard at the time of a visit to the clinic or at hospitalization. Confirmation of the asthma diagnosis was based on an audit by a pediatric pulmonologist documenting more than one episode of wheezing. The medical records of 324 children with SCA were reviewed. Among this group, 297 children were evaluated for a doctor-diagnosis of asthma, for a total of 1,805 patient-years. Seventy-nine percent of the cohort children were born in France (235 out of 297). In the cohort, 8.4% (25 out of 297) of the children had a doctor-diagnosis of asthma (Table 1). The rate of ACS was significantly increased in those with asthma diagnosis (0.31 events per patient year for those with asthma and 0.16 events per patient year for those without asthma, p value=0.03). Gender, white blood cell count, percent fetal hemoglobin, and baseline